苯海拉明联合泼尼松预防碘造影剂过敏反应的临床观察
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篇名: 苯海拉明联合泼尼松预防碘造影剂过敏反应的临床观察
TITLE:
摘要: 目的:观察苯海拉明联合泼尼松预防碘造影剂过敏反应的成功率和安全性。方法:42例碘过敏试验呈阳性患者于术前1 d给予泼尼松片40 mg,口服,每日3次,术前1 h给予苯海拉明50 mg,肌内注射,并同时静脉注射碘造影剂1 ml(再次进行过敏试验)。所有患者使用碘造影剂15 min后若不存在支气管痉挛、血管性水肿、皮团样皮疹、低血压、瘙痒等过敏反应,方可行血管介入治疗。观察42例患者预防成功率及不良反应发生情况。结果:预防成功率为90.48%;不良反应发生率为7.14%,经停药后症状均自行好转。结论:苯海拉明联合泼尼松预防碘造影剂过敏反应具有较高的成功率,安全性较好。
ABSTRACT: OBJECTIVE:To observe the success rate and safety of diphenhydramine combined with prednisone in the prevention of iodine-containing contrast agent allergic reactions. METHODS: 1 day before surgery, 42 patients with positive iodine allergy test was given 40 mg Prednisone tablet, orally, 3 times a day, 50 mg diphenhydramine was given by intramuscular injection and 1 ml iodine contrast by intravenous injection (allergy test performed again)1 h before surgery. After all patients used iodine contrast in 15 min, vascular interventional treatment was conducted if there was no bronchospasm, angioedema, leather ball sample itchy rash, hypotension, itching and other allergic reactions. Prevention success rate were observed, and the incidence of adverse reactions was recorded. RESULTS: Prevention success rate was 90.48%, the incidence of adverse reactions was 7.14%, and it self-improved after stopping drugs. CONCLUSIONS: Diphenhydramine combined with prednisone has high success rate in the prevention of iodine-containing contrast agent allergic reactions, with good safety.
期刊: 2016年第27卷第6期
作者: 胡立禄,高全清,刘振良
AUTHORS: HU Lilu,GAO Quanqing,LIU Zhenliang
关键字: 苯海拉明;泼尼松;碘造影剂过敏;预防成功率;安全性
KEYWORDS: Diphenhydramine; Prednisone; Iodine contrast allergy; Prevention success rate; Safety
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