万古霉素致儿童中性粒细胞减少不良反应/不良事件分析
x

请在关注微信后,向客服人员索取文件

篇名: 万古霉素致儿童中性粒细胞减少不良反应/不良事件分析
TITLE:
摘要: 目的:为临床判断万古霉素致中性粒细胞减少不良反应/不良事件提供参考。方法:以1例骨髓炎患儿长疗程、大剂量使用万古霉素后致中性粒细胞减少为例,同时检索PubMed、中国知网数据库中的相关文献,并结合文献进行分析。结果:根据中国国家药品不良反应因果关系准则,该患儿中性粒细胞减少可能与输注万古霉素有关。结论:万古霉素致儿童中性粒细胞减少与输注该药后引起的药物蓄积有关,一旦发生不良反应/不良事件应减少万古霉素剂量或停药,同时密切监测血常规及血药浓度。
ABSTRACT: OBJECTIVE:To provide reference for vancomycin-induced neutropenia adverse reactions/adverse events in clinical diagnosis. METHODS: With a case of children with neutropenia treated by long-course and large-dose vancomycin, PubMed and CNKI were retrieved to collect related literature and the literature was analyzed. RESULTS: Neutropenia may be associated with vancomycin, based on causality criterion of adverse reaction in China. CONCLUSIONS: Vancomycin-induced neutropenia in children is most likely associated with prolonged exposure induced by infusion, vancomycin dosage should be reduced or stopped, and routine blood and plasma concentration should be closely monitored.
期刊: 2016年第27卷第6期
作者: 季欢欢,罗健,宋林,周波,田晓颖,贾运涛
AUTHORS: JI Huanhuan,LUO Jian,SONG Lin,ZHOU Bo,TIAN Xiaoying,JIA Yuntao
关键字: 万古霉素;中性粒细胞减少;相关性;儿童;不良反应/不良事件
KEYWORDS: Vancomycin; Neutropenia; Correlation; Children; ADR/ADE
阅读数: 459 次
本月下载数: 10 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!