帕罗西汀联合小剂量奥氮平对抑郁症伴失眠患者睡眠进程和睡眠结构的影
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篇名: 帕罗西汀联合小剂量奥氮平对抑郁症伴失眠患者睡眠进程和睡眠结构的影
TITLE:
摘要: 目的:探讨帕罗西汀联合小剂量奥氮平对抑郁症伴失眠患者睡眠进程和睡眠结构的影响。方法:84例抑郁症伴失眠患者随机均分为对照组和观察组。对照组患者给予帕罗西汀片20 mg,每日早晨口服1次;观察组患者在对照组治疗的基础上加用奥氮平片2.5 mg,每日睡前口服1次。观察两组患者治疗前和治疗3、6个月后的睡眠质量[匹兹堡睡眠质量指数(PSQI)]、抑郁情绪评分[汉密顿抑郁量表(HAMD)]、睡眠进程[睡眠潜伏期(SL)、觉醒次数(AT)、实际睡眠总时间(TST)、睡眠效率(SE)、快速眼球运动睡眠(REM)潜伏期(RL)]和睡眠结构[睡眠阶段1(S1)、2(S2)、3(S3)和REM占睡眠时间的比例],并记录不良反应发生情况。结果:治疗后,两组患者PSQI、HAMD评分均显著低于同组治疗前,且随时间延长逐渐降低,观察组低于对照组;观察组患者TST显著高于治疗前和对照组,S1占睡眠比例显著低于同组治疗前;两组患者SE、S3和REM占睡眠比例均显著高于同组治疗前,且观察组高于对照组,SL、AT、RL、S2占睡眠比例均显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间未见明显不良反应发生。结论:帕罗西汀联合小剂量奥氮平能显著改善患者抑郁情绪,优化睡眠进程和睡眠结构,提高睡眠质量。
ABSTRACT: OBJECTIVE:To study the effect of paroxetine combined with low dose of olanzapine on sleep process and architecture of depression patients with insomnia. METHODS: 84 depression patients with insomnia were randomly divided into control group and observation group. Control group was given 20 mg Paroxetine tablet, once every morning; observation group was additionally given 2.5 mg Olanzapine tablet, once before going to bed. Sleep quality [Pittsburgh Sleep Quality Index (PSQI)], depression scores [Hamilton Depression Scale (HAMD)], sleep process [sleep latency (SL), awakening times (AT), the actual total sleep time (TST), sleep efficiency (SE), rapid eye movement (REM) sleep latency (RL)] and sleep architecture [sleep stage 1 (S1),2(S2),3(S3) and the proportion of REM to sleep] in 2 groups before and 3, 6 months after treatment and the incidence of adverse reactions(ADR) were observed. RESULTS: After treatment, PSQI and HAMD scores in 2 groups were significantly lower than before, and gradually decreased by time, and observation group was lower than control group; TST in observation group was significantly higher than before and control group, S1 in observation group was significantly lower than before, SE, S3 and REM in 2 groups were significantly higher than before, and observation group was higher than control group, SL, AT, RL and S2 were significantly lower than before, and observation group was lower than control group, the differences were statistically significant(P<0.05). There were no obvious ADR in 2 groups. CONCLUSIONS: Paroxetine combined with low dose of olanzapine can significantly relieve depression, optimize sleep process and sleep architecture, then impove sleep quality.
期刊: 2016年第27卷第6期
作者: 杨冬林,刘立芬,郝英霞,栾清明
AUTHORS: YANG Donglin,LIU Lifen,HAO Yingxia,LUAN Qingming
关键字: 帕罗西汀;奥氮平;抑郁症;失眠;睡眠进程;睡眠结构
KEYWORDS: Paroxetine; Olanzapine; Depression; Insomnia; Sleep process; Sleep architecture
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