|目的：观察奥硝唑联合金栀洁龈含漱液治疗急性智齿冠周炎的疗效和安全性。方法： 110例急性智齿冠周炎患者随机均分为对照组和观察组。对照组患者给予奥硝唑片1片研磨成细粉，装入无菌瓶中备用。治疗前仔细检查口腔，采用无菌注射器吸取双氧水（3％）和0.9％氯化钠注射液反复、交替冲洗冠周组织，将盲袋内的食物残渣、细菌和脓液全部清理干净，直到溢出液澄清无脓性为止；用无菌棉球吸干管周组织并隔湿，用探针分开牙龈瓣，将奥硝唑细粉装入盲袋中，放置棉球将奥硝唑粉末压入龈瓣深处并保留棉球，每日1 次，另加服阿莫西林胶囊2粒，每日3次。观察组患者在对照组治疗的基础上于“溢出液澄清无脓性为止”后，给予金栀洁龈含漱液10 ml包含口中3 min，重复2次，再将奥硝唑细粉放入盲袋中；并于每日3餐后，取10 ml含漱液含漱3 min。两组疗程均为4 d。观察两组患者的临床疗效，治疗前后各主症及主症总评分、各次症及次症总评分及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）；治疗后，两组患者各主症及主症总评分、各次症及次症总评分均显著低于同组治疗前，且观察组显著低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：奥硝唑联合金栀洁龈含漱液治疗急性智齿冠周炎的疗效显著优于单用奥硝唑，可显著降低主症和次症评分，且安全性相当。
|OBJECTIVE： To observe the efficacy and safety of ornidazole combined with Jinzhi jieyin gargle in the treatment of acute wisdom tooth pericoronitis. METHODS： 110 patients with acute wisdom tooth pericoronitis were randomly divided into control group and observation group. Control group was given one Ornidazole tablet， ground into fine powder in sterile bottle. Checking oral cavity carefully before treatment， Hydrogen peroxide solution （3％） and 0.9％ Sodium chloride injection were in sterile syringe to repeatedly and alternatively flushing peripheral tissue to clean the food residuals， bacteria and pus in gingival pocket， until spilled solution was clear and no purulent. Sterile cotton swabs were used to blot up and separate it from the wet. After separating gingival valve by probe， ornidazole fine powder was put into gingival pocket and pressed into deep area by tampons， and kept tampons， once a day + 2 Amoxicillin capsules， 3 times a day. Observation group was additionally given 10 ml Jinzhi jieyin gargle in mouth for 3 min after the spilled solution was clear and no purulent， for 2 times， then ornidazole fine powder was put into blind pouch. 10 ml was taken in mouth for 3 min after three meals per day. The treatment course for both groups was 4 d. Clinical efficacy， main symptom and total scores of main symptoms， secondary symptom and total scores of secondary symptoms before and after treatment， and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant （P＜0.05）； after treatment， main symptom and total scores of main symptoms， secondary symptom and total scores of secondary symptoms in 2 groups were significantly lower than before， and observation group was significantly lower than control group， the differences were statistically significant（P＜0.05）. And there was no significant difference in the incidence of adverse reactions between 2 groups（P＞0.05）. CONCLUSIONS： Ornidazole combined with Jinzhi jieyin gargle has better efficacy than only ornidazole in the treatment of acute wisdom tooth pericoronitis， it can significantly reduce the main symptom scores and secondary symptom scores， with similar safety.
|LI Yaping，XU Qinghui
|Acute wisdom tooth pericoronitis； Ornidazole； Jinzhi jieyin gargle； Efficacy； Safety