八珍汤加减联合抗菌药物治疗气血两虚型产后发热的临床观察
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篇名: 八珍汤加减联合抗菌药物治疗气血两虚型产后发热的临床观察
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摘要: 目的:探讨八珍汤加减联合抗菌药物治疗气血两虚型产后发热的临床疗效及安全性。方法:选取我院2014年12月-2016年6月收治的气血两虚型产后发热患者94例,按随机数字表法分为对照组和观察组,各47例。对照组患者给予注射用头孢唑林钠3 g加入氯化钠注射液250 mL中,ivgtt,bid;若连续2 d体温未下降,则给予注射用阿奇霉素250 mg加入氯化钠注射液250 mL中,ivgtt,bid;体温超过38.5 ℃者肌内注射复方氨林巴比妥注射液2 mL。观察组患者在对照组基础上给予八珍汤加减治疗。两组患者疗程均为5 d。比较两组患者临床疗效及治疗前后白细胞计数、血浆C反应蛋白(CRP)、血浆黏度、血浆纤维蛋白原(Fib)水平,观察两组患者退热时间、住院时间及不良反应发生情况。结果:观察组患者总有效率为95.75%,显著高于对照组的78.72%,差异有统计学意义(P<0.05)。治疗前,两组患者白细胞计数、CRP、血浆黏度、Fib水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者白细胞计数、CRP、血浆黏度、Fib水平均显著下降,且观察组水平显著低于对照组,差异均有统计学意义(P<0.05)。观察组患者退热时间和住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应发生率为6.38%,显著低于对照组的23.40%,差异有统计学意义(P<0.05)。结论:八珍汤加减联合抗菌药物治疗气血两虚型产后发热疗效显著,能明显改善患者炎症状态和血浆黏度,加快患者退热,且安全性高。
ABSTRACT: OBJECTIVE: To investigate the clinical efficacy and safety of modified Bazhen decoction combined with antibiotics in the treatment of postpartum fever with qi-blood deficiency. METHODS: Totally 94 cases of postpartum fever with qi-blood deficiency selected from our hospital during Dec. 2014-Jun. 2016 were divided into control group and observation group according to random number table, with 47 cases in each group. Control group was given Cefazolin sodium for injection 3 g added into Sodium chloride injection 250 mL, ivgtt, bid; and given Azithromycin for injection 250 mg added into Sodium chloride injection 250 mL, ivgtt, bid if body temperature did not drop for consecutive 2 days; the patients with body temperature over 38.5 ℃ were given Compound aminophenazone and barbital injection 2 mL intramuscularly. Observation group was additionally given modified Bazhen decoction on the basis of control group. Treatment course of 2 groups lasted for 5 d. Clinical efficacies were compared between 2 groups as well as white blood cell count, plasma C reactive protein (CRP), plasma viscosity and fibrinogen (Fib) before and after treatment. The antipyretic time, hospitalization time and the occurrence of ADR were observed in 2 groups. RESULTS: The total response rate of observation group was 95.75%, which was significantly higher than 78.72% of control group, with statistical significance (P<0.05). Before treatment, there was no statistical significance in white blood cell count, CRP, plasma viscosity or Fib between 2 groups (P>0.05). After treatment, white blood cell count, CRP, plasma viscosity and Fib of 2 groups were decreased significantly, and the observation group was significantly lower than the control group, with statistical significance (P<0.05). The antipyretic time and hospitalization time of observation group were shorter than those of control group, with statistical significance (P<0.05). The incidence of ADR in observation group was 6.38%, which was significantly lower than 23.40% of control group, with statistical significance (P<0.05). CONCLUSIONS: Modified Bazhen decoction combined with antibiotics in the treatment of postpartum fever with qi-blood deficiency can significantly improve inflammation status and plasma viscosity, and speed up defervescence with good safety.
期刊: 2017年第28卷第17期
作者: 马万增,杨静,王山
AUTHORS: MA Wanzeng,YANG Jing,WANG Shan
关键字: 八珍汤;抗菌药物;气血两虚型;产后发热
KEYWORDS: Bazhen decoction; Antibiotics; Qi-blood deficiency; Postpartum fever
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