双歧杆菌三联活菌胶囊辅助治疗伴有焦虑抑郁的幽门螺杆菌阳性慢性萎缩性胃炎的临床观察
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篇名: 双歧杆菌三联活菌胶囊辅助治疗伴有焦虑抑郁的幽门螺杆菌阳性慢性萎缩性胃炎的临床观察
TITLE:
摘要: 目的:观察双歧杆菌三联活菌胶囊辅助治疗伴有焦虑抑郁的幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)的临床疗效及安全性。方法:将伴有焦虑抑郁的Hp阳性CAG患者100例按随机数字表法分为对照组和观察组,各50例。对照组患者给予标准三联疗法(雷贝拉唑+阿莫西林克拉维酸+左氧氟沙星)治疗;观察组患者在对照组基础上加用双歧杆菌三联活菌胶囊0.42 g,tid。两组患者疗程均为14 d。观察两组患者临床疗效、Hp根除率及治疗前后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分,并比较不良反应发生情况。结果:观察组患者临床总有效率为94.0%、Hp根除率为92.0%,明显高于对照组的76.0%与78.0%,差异均有统计学意义(P<0.05)。治疗前,两组患者HAMA、HAMD评分比较,差异均无统计学意义(P>0.05);治疗后,两组患者HAMA、HAMD评分显著降低,且观察组评分显著低于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率为4.0%,显著低于对照组的20.0%,差异有统计学意义(P<0.05)。结论:双歧杆菌三联活菌胶囊辅助治疗伴有焦虑抑郁的Hp阳性CAG疗效显著,可显著提高Hp根除率,明显改善患者焦虑抑郁状态,降低不良反应发生率。
ABSTRACT: OBJECTIVE: To observe clinical efficacy and safety of Bifidobacterium triple viable capsules in the adjunctive treatment of Helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG) complicated with anxiety-depression. METHODS: A total of 100 Hp positive CAG patients with anxiety-depression were divided into control group and observation group according to random number table, with 50 cases in each group. Control group was given standard triple therapy (rabeprazole+amoxicillin and clavulanate+levofloxacin). Observation group was additionally given Bifidobacterium triple viable capsules 0.42 g, tid. The treatment lasted for 14 d in both groups.  Clinical efficacies, Hp eradication rates as well as HAMA and HAMD scores before and after treatment were all observed in 2 group. The occurrence of ADR was compared. RESULTS: Total response rate of observation group was 94.0%, and Hp eradication rate was 92.0%, which were significantly higher than 76.0% and 78.0% of control group, with statistical significance (P<0.05). Before treatment, there was no statistical significance in HAMA and HAMD scores in 2 groups (P>0.05). After treatment, HAMA and HAMD scores of 2 groups were decreased significantly, the observation group was significantly lower than the control group, with statistical significance (P<0.05). The incidence of ADR in observation group (4.0%) was significantly lower than control group (20.0%), with statistical significance (P<0.05). CONCLUSIONS: Adjunctive use of Bifidobacterium triple viable capsules can significantly improve Hp eradication rate, clinical symptom, anxiety and depression, while reduce the incidence of ADR.
期刊: 2017年第28卷第17期
作者: 石永强,赵向阳,王小平,陈跃,王辉,吴新国,荆扬,宋用强
AUTHORS: SHI Yongqiang,ZHAO Xiangyang,WANG Xiaoping,CHEN Yue,WANG Hui,WU Xinguo,JING Yang,SONG Yongqiang
关键字: 益生菌;慢性萎缩性胃炎;焦虑;抑郁;幽门螺杆菌;双歧杆菌三联活菌胶囊
KEYWORDS: Probiotics; Chronic atrophic gastritis; Anxiety; Depression; Helicobacter pylori; Bifidobacterium triple viable capsules
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